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氧氟沙星三元配合物的光谱分析新方法研究及应用
孙 洁, 徐丽芳, 陆 斐, 陶建伟, 陆鸣杰
上海应用技术学院
摘要:
以水-乙醇作为溶剂,在pH为5.8的磷酸二氢钾-氢氧化钠缓冲溶液中,氧氟沙星与茜素、稀土镧离子反应形成三元配合物体系.紫外吸收光谱研究结果表明:该三元配合物体系在295 nm处有最大吸收波长,表观摩尔吸收系数为3.60×104 L·mol-1·cm-1.氧氟沙星在0.54~30.36 mg/L范围内符合朗伯-比尔定律,方法的检出限为0.02 mg/L.用于市售药品的含量分析,得回收率为93.9%~97.11%,相对标准偏差为0.65%~1.29%.
关键词:  氧氟沙星  稀土元素  紫外分光光度法
DOI:
分类号:
基金项目:上海市教委自然科学基金(03HK13); 上海市优秀青年教师专项基金(405ZK11YQ12-yyy11029)
The research and application of a new spectrophotometric method for ofloxacin ternary complex
SUN Jie, XU Lifang, LU Fei, TAO Jianwei, LU Mingjie
School of Chemical and Environmental Engineering,Shanghai Institute of Technology
Abstract:
Lanthanum(Ⅲ) ion is coordinated with ofloxacinand and alizarin to form a rare earth ternary complex with potassium dihydrogen phosphate - sodium hydroxide buffer solution ( pH = 5.8) in the solvent of ethanol. The absorption peak of the rare earth ternary complex is centered at 295 nm. Its apparent molar absorptivity at 295.0 nm is 3.60×104 L·mol-1·cm-1. The linear range was 0.54~30.36 mg·L-1 with a detection limit of 0.012 mg·L-1.It′s a simple, rapid, and convenient method for the determination of the investigated drug in tablet.
Key words:  ofloxacin  lanthanon  UV spectrophotometric method