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聚多巴胺/银复合纳米粒子的制备及其在细胞荧光/表面增强拉曼双成像中的应用
周延玲, 陈偲, 周亚蕾, 杨晓彤, 王丰, 杨海峰
上海师范大学
摘要:
提出了一种具有荧光/表面增强拉曼光散射(SERS)双成像能力的复合纳米粒子的简便制备方法.在银纳米粒子表面修饰上4-巯基吡啶,再在其表面包裹聚多巴胺膜并吸附罗丹明6G.选择合适的激发波长,获得了良好的细胞的荧光和SERS图像,研究了肿瘤细胞的荧光/SERS双成像与药物释放.这种具有荧光/SERS双成像能力的复合纳米粒子有望在生物体成像和药物控释等领域获得应用.
关键词:  荧光成像  表面增强拉曼散射  双光学纳米粒子  细胞成像
DOI:
分类号:
基金项目:国家自然科学基金面上项目(21475088);上海市科学技术委员会基金项目(14ZR1430200)
Preparation of polydopamine/silver composite nanoparticles for cell fluorescence/SERS dual-mode imaging
ZHOU Yanling, CHEN Si, ZHOU Yalei, YANG Xiaotong, WANG Feng, YANG Haifeng
College of Life and Environmental Sciences,Shanghai Normal University
Abstract:
A simple method for preparation of a dual mode composite nanoparticles,which combine fluorescence and surface-enhanced Raman scattering (SERS) imaging capability,is proposed in this paper.4-mercaptopyridine coated silver nanopaticles (AgNPs) were used to generate SERS signal,a thin layer of polydopamine was then coated on AgNPs to adsorb fluorescent rhodamine 6G to generate fluorescence signal.The composite nanoparticles that we gained show good image and drug release capability for cancer cell when excited by lasers with proper wavelength,which provide good prospect in application for organism image and drug controlled delivery.
Key words:  fluorescence imaging  surface-enhanced Raman scattering  dual-mode imaging  composite nanoparticle