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阿霉素负载的Fe5C2纳米粒子在光热治疗/化疗中的研究
王丹利, 王俊, 周治国, 杨仕平
上海师范大学
摘要:
采用高温热解法制备了粒径均一的Fe5C2磁性纳米粒子,并在其表面包裹磷脂改善纳米粒子的水溶性和稳定性,同时在纳米粒子表面负载阿霉素(DOX)实现化疗作用.阿霉素负载的Fe5C2磁性纳米粒子(Fe5C2-DOX-DSPE-mPEG),不仅具有一定的磁学性质,且具有优良的光热转化效率.细胞实验说明该纳米粒子对肿瘤细胞具有光热治疗和化疗协同治疗作用.
关键词:  Fe5C2纳米粒子  光热治疗  化疗  协同治疗
DOI:
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基金项目:国家自然科学基金(21571130)
Study of Fe5C2 nanoparticlesloaded with doxorubicin for photothermal therapy and chemotherapy
WANG Danli, WANG Jun, ZHOU Zhiguo, YANG Shiping
College of Life and Environmental Sciences,Shanghai Normal University
Abstract:
In this paper,uniform sized Fe5C2 magnetic nanoparticles were synthesized bythermaldecomposition method.The materials modified with phospholipids have good solubility in water and physiological stability.Meanwhile,nanoparticles have been loaded with doxorubicin (DOX) to achieve chemotherapy.Fe5C2-DOX-DSPE-mPEG nanoparticles havenot only magnetic propertiesbut high photothermal conversion efficiency.Cell experiments showed that Fe5C2-DSPE-mPEG loaded with DOX has a significant synergistic effect ofphotothermaltherapy and chemotherapy.
Key words:  Fe5C2 magnetic nanoparticles  photothermal therapy  chemotherapy  synergistic therapeutic