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具有不同N^N配体的金属铱配合物长磷光性质
侯雨桐, 周治国, 杨红, 杨仕平
上海师范大学 化学与材料科学学院, 上海 200234
摘要:
长磷光成像是指移除激发光源后的延迟发光,它无需实时激发光的照射,相比传统荧光成像有更高的信噪比.为了研究铱(Ir)配合物的长磷光性质,设计了3种C^N配体相同,而N^N配体不同的Ir配合物,在溶液层次研究了它们的长磷光性质.经过比较,将长磷光强度最强的3,8-二溴邻菲罗啉配合物制备成纳米粒子,在小鼠背部皮下进行长磷光成像,与荧光成像对比,呈现出更高的信噪比.
关键词:  铱(Ir)配合物  长磷光  活体光学成像
DOI:10.3969/J.ISSN.1000-5137.2020.02.003
分类号:O614.82+5
基金项目:国家自然科学基金(21877080)
Long phosphorescence properties of iridium complexes with different N^N ligands
HOU Yutong, ZHOU Zhiguo, YANG Hong, YANG Shiping
College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China
Abstract:
Long phosphorescence imaging eliminates the real-time light irradiation and gets a higher signal-to-noise ratio than traditional fluorescence imaging. In order to study the long phosphorescence properties of iridium (Ir) complexes, we designed three kinds of iridium complexes with the same C^N ligands and different N^N ligands were designed.After comparison, the 3, 8-dibromophenanthroline iridium complexes showed the strongest phosphorescence intensity and were prepared into watersoluble nanoparticles. Long phosphorescent imaging was performed subcutaneously on the back of mice, which showed a higher signal-to-noise ratio compared with fluorescence imaging.
Key words:  iridium(Ir)complexes  long phosphorescence  in vivo optical imaging