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白蛋白调控的铁酚配位聚合物在肿瘤诊疗中的应用
万莹, 程玉莹, 母雪玲, 蔡宇, 田启威, 杨仕平
上海师范大学 化学与材料科学学院, 上海 200234
摘要:
配位聚合物由于其独特的理化性质而备受关注,纳米级配位聚合物更是由于其独特的生物活性等而被广泛应用于生物医药领域.铁酚类配位聚合物由于具有较好的生物兼容性、较强的近红外吸收性以及独特的磁学性能而被广泛研究.因此,本课题组近年来通过白蛋白独特的结构,仿生矿化合成了多种具有纳米结构的铁酚类配位聚合物,研究了其磁共振成像(MRI)、光声成像(PA)以及光热治疗功能,主要概述了白蛋白调控的铁酚类配位聚合物的研究进展,并进一步探讨了该研究工作的方向.
关键词:  配位聚合物  铁酚配位聚合物  磁共振成像(MRI)  光声成像(PA)  抗癌治疗
DOI:10.3969/J.ISSN.1000-5137.2021.01.003
分类号:O614.81
基金项目:上海市自然科学基金探索类项目(20ZR1472300);国家自然科学基金重大研究计划培育项目(91959105)
Application of albumin-regulated iron phenol coordination polymer in tumor theranostics
WAN Ying, CHENG Yuying, MU Xueling, CAI Yu, TIAN Qiwei, YANG Shiping
College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China
Abstract:
Coordination polymers have attracted much attention due to their unique physical and chemical properties, and nanoscale coordination polymers have been widely used in the field of biomedicine because of their unique biological activities. Iron phenolic coordination polymers have been extensively studied owing to their good biocompatibility, strong near-infrared absorption properties,and unique magnetic properties. Hence,in recent years,our group has synthesized a variety of iron phenolic coordination polymers with nanostructures through the unique structure of albumin by biomimetic mineralization. Meanwhile, the magnetic resonance imaging(MRI), photoacoustic imaging(PA), and photothermal therapy performance of the iron phenolic coordination polymer nanoparticles also were investigated. This paper mainly summarizes the research progress of our group in the coordination polymerization of iron phenols regulated by albumin, and further discusses the direction of this research work.
Key words:  coordination polymers  iron phenolic coordination polymers  magnetic resonance imaging(MRI)  photoacoustic imaging(PA)  tumor therapy